A joint computational chemistry postdoctoral position is available in Eck lab and Computational Chemistry Core for a motivated individual to develop and apply cutting-edge computational techniques to guide the design and optimization of small molecule modulators for RAS/RAF pathway activated mutant EGFR and other cancer drug targets. The Eck lab uses structural biochemical and biophysical methods to study signal transduction of kinases and other protein molecules. The Computational Chemistry Core in the Department of Cancer Biology applies molecular modeling approaches to study interactions between small molecules and receptors. The candidate will closely work with chemists structural biologists and cell biologists to advance ligand design and understanding of small-molecule perturbation of signaling.

Located in Boston and the surrounding communities Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer HIV/AIDS and related diseases. We strive to create an inclusive diverse and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment we educate tomorrow's physician/researchers and we work with amazing partners including other Harvard Medical School-affiliated hospitals.

Primary duties and responsibilities:

• Work closely with medicinal chemists to guide the optimization of lead compounds
• Collaborate with structural biologists and cell biologists to provide molecule models for interpreting experimental data
• Participate actively in the development of novel computational methods for design small molecule probes
• Maintain clear and accurate records of research work (e.g. research methods results/findings)

Qualifications:

• PhD in computational chemistry computational biophysics or related fields.
• Experienced in structural and ligand based small molecule drug design.
• Experienced in molecular dynamics simulation and protein protein docking.
• Ability to analyze experimental data prepare research publications and communicate results.
• Programming/scripting skills are important for this position.

At Dana-Farber Cancer Institute we work every day to create an innovative caring and inclusive environment where every patient family and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals neither do we. If working in this kind of organization inspires you we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race color religion sex gender identity or expression national origin sexual orientation genetic information disability age ancestry military service protected veteran status or other groups as protected by law.