Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Sr. Scientist, Computational Chemistry at our recently dedicated San Diego Research Site. At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Here, you will be a vital contributor to our inspiring, bold mission. As a Sr. Scientist - Computational Chemistry, you will be empowered to serve on project teams for discovery to development programs. OBJECTIVES/PURPOSE Work as part of a multi-disciplinary team of medicinal chemists, structural biologists, and biologists and provide computational expertise to advance drug discovery projects Contribute to drug discovery efforts across a variety of modalities such as small molecule, peptides, and oligonucleotides Participate in the implementation and execution of innovative computational methodologies and tools such as AI approaches to support drug discovery efforts ACCOUNTABILITIES Demonstrate an understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment Independently design, develop and execute research assignments, contributing to multiple projects Contribute to the identification, development, validation, and implementation of innovative computational approaches that improve research productivity and success Provide important technical knowledge and strategic input to project teams to drive decision making in drug discovery projects Communicate research efforts and results at internal scientific meetings and with collaborators DIMENSIONS AND ASPECTS Technical/Functional (Line) Expertise Experience with a variety of computational tools and methodology including docking, virtual screening, molecular dynamics, free energy perturbation, homology modeling, quantum mechanics, pharmacophore elucidation, machine learning Comprehensive experience in data mining and data analysis Provide project teams with computational strategies to inform, influence, and prioritize designs for potency/selectivity and improve ADME/Tox endpoints. Contribute to the development and deployment of design and/or AI platforms to impact drug discovery Identify and implement novel computational chemistry algorithms and technologies Familiarity with standard computational chemistry software packages including Schrodinger drug discovery toolkit, LiveDesign, MOE(CCG), StarDrop (Optibrium), Dotmatics, OpenEye, Pipeline pilot, Knime Proficiency in scientific scripting and programming languages Leadership Develop and oversee novel scientific projects Decision-making and Autonomy Independently manage workload and expectations Scientifically independent Interaction Collaborate with others, and acts as scientific resource for an aspect of a program Positive can-do attitude with excellent communication and collaboration skills and ability to work with cross functional scientists. Ability to clearly and concisely convey ideas and opinions Innovation Play a leading role in the identification, development, validation, and implementation of innovative and computational approaches that improve research productivity and success EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS: PhD degree in physical organic chemistry, computational chemistry or a related field with 5+ years of experience MS with 10+ years of experience, or BS with 12+ years of experience WHAT TAKEDA CAN OFFER YOU: 401(k) with company match and Annual Retirement Contribution Plan Tuition reimbursement Company match of charitable contributions Health & Wellness programs including onsite flu shots and health screenings Generous time off for vacation and the option to purchase additional vacation days Community Outreach Programs Empowering Our People to Shine Learn more at takedajobs.com. No Phone Calls or Recruiters Please.
