Organisation Name: The Structural Genomics Consortium, University of Toronto
Organisation Type:
City:
State:
Country:
Job Description:
The Structural Genomics Consortium, University of Toronto, is seeking an experienced and creative computational chemist to join a fast-paced, multi-disciplinary group of biophysical experimentalists, structural and cell biologists. You will use computational chemistry to design and optimize chemical probes (small molecule drug-like inhibitors) that target epigenetic regulatory proteins and ubiquitin-mediated signaling pathways, such as E3 ligases and WDR containing proteins. Qualifications Receptor-based and ligand based virtual screening Compound prioritization using free energy perturbation Experience working in multidisciplinary environment. Strong organizational, team and communication skills. PhD obtained within the last 5 years. Interested candidates please send CV and cover letter to matthieu.schapira@utoronto.ca Selected publications relating to the project: Arrowsmith CH, Bountra C, Fish PV, Lee K, Schapira M (2012) Epigenetic protein families: a new frontier for drug discovery. Nat Rev Drug Discov. 11:384-400 Schapira M, Tyers M, Torrent M, Arrowsmith CH (2017) WD40 repeat domain proteins: a novel target class? Nat Rev Drug Discov. 16(11):773-786 Schapira M, Calabrese MF, Bullock AN, Cres CM (2019) Targeted protein degradation: expanding the toolbox. Nat Rev Drug Discov 18(12):949-963 The SGC is a not for profit, public-private partnership working with academia and nine pharmaceutical companies to carry out open access science relevant to human health and drug discovery. www.thesgc.org, www.thesgc.org/chemical-probes/epigenetics The University of Toronto and its affiliated hospital research institutes comprise one of the largest and most productive centers of biomedical research in North America. Located in vibrant downtown Toronto, the University provides an outstanding opportunity for scientific research, and career development.
