Senior Scientist, Cellular and Computational Toxicology, Predictive, Investigative and Translational Toxicology (PITT) - Spring
Organisation Name: Johnson & Johnson Family of Companies
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Job Description:
Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies, is recruiting for a Senior Scientist, Cellular and Computational Toxicology, Predictive, Investigative and Translational Toxicology (PITT), located in Spring House, PA. At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies. Key Responsibilities: As part of the Global Predictive, Investigative and Translational Toxicology (PITT) Team, the candidate is expected to work within interdisciplinary teams in and across Nonclinical Safety to provide safety support to early discovery teams and engage in core activities within the Cellular and Computational Toxicology group Work as part of a team of safety assessment scientists and more broadly with DMPK, medicinal chemistry, pharmacology and computational experts to contribute towards the implementation of discovery toxicology strategic plans to enable the selection and progression of optimized drug candidates Apply novel toxicity mechanism-based translational assays and integrated models to support early target safety and chemistry evaluation. Provide pharmaceutical drug project teams with expert advice and direction to improve the quality of therapeutics selected for further development based on proactive risk assessment of target- and chemotype-related toxicities Help to develop comprehensive target safety reviews with risk mitigation plan for early drug discovery project teams based on literature, bioinformatics, and other predictive tools. Where possible, apply ‘state of the art’ in silico, in vitro, and in vivo de-risking strategies to aid in the selection and optimization of large and small molecule therapeutics, as well as new therapeutic modalities Lead the development of early hypothesis-driven investigation into mechanisms of toxicity for the proactive management of potential safety liabilities and communication of impact to teams Harness biosignature platform readouts for early safety mitigation, Tier 2 assay development and NEXGEN innovation Interface with computational toxicology, data sciences, PMO to monitor attrition and the impact of improved science and processes over time. Represent PITT in cross-functional project and issue resolution teams Manage internal and external collaborative issue resolution and innovation projects This role might have direct reports as well as matrix reports. Qualifications: PhD in a scientific discipline with at least 3 years of experience working at a pharmaceutical company is required A proven track record in prominent roles supporting cross-functional toxicology teams for investigative work, issue resolution and innovation projects is required. Deep insights into cellular and pathway mechanisms, coupled with knowledge of system toxicology and data sciences in order to provide expert advice and direction to improve the quality of therapeutics is required. Passion for safety related attrition in drug discovery is required Passion for data driven science and systems toxicology (proficiency in Spotfire, Stardrop, would be a bonus) is required Demonstrated project team experience at a pharmaceutical company and ability to work effectively in a matrix, global environment as part of a multidisciplinary team is required Broad scientific knowledge including pharmacology, toxicology, physiology and biochemistry is preferred. Experience in development across mixed modalities is preferred Strong interpersonal and organizational skills are required Excellent oral and written communication skills are required This position is located in Spring House, PA, and may require about 10% travel. Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
