Turning Point Therapeutics is a clinical-stage precision oncology company with a pipeline of internally discovered investigational drugs designed to address key limitations of existing cancer therapies. The company’s lead program, repotrectinib, is a next-generation kinase inhibitor targeting genetic drivers of non-small cell lung cancer and advanced solid tumors. Turning Point Therapeutics is building their drug discovery pipeline of precision medicines and are driven to develop therapies that mark a turning point for patients in their cancer treatment. We are currently recruiting a Senior Design/Computational Chemist to join our multidisciplinary drug discovery team. The successful candidate will support (with the potential to lead) project teams from target identification through lead optimization and ultimately drug candidate selection. The candidate will be a motivated, independent researcher with deep experience in molecular design, particularly protein structure-based design, and computational chemistry techniques applied to a disciplined medicinal chemistry effort. The qualified candidate will be creative and detail-oriented with a passion for small molecule drug discovery and strategy. The candidate will work collaboratively with medicinal chemists and project teams to design compounds with improved potency, selectivity, functional activity, and ADMET properties. As an active member of the design team, the candidate will apply their design skills and will bring broad insight into chemistry and other disciplines to bear on advancing projects. Desired Skills and Experience: Senior computational chemist having strong expertise in ligand design as well as protein structure-based drug design such as ligand modeling, stereoelectronic interactions, conformational analysis, ab initio calculations, and homology modeling. Deep experience with kinases, low molecular weight kinase inhibitor design and FBDD is a plus. Ph.D. or equivalent in computational chemistry, cheminformatics, physics, or chemistry with >10 yrs industrial experience applied to small-molecule drug discovery. Strong familiarity with physicochemical properties as they relate to drug design/development and application of ligand efficiency (LE) and lipid ligand efficiency (LLE) principles to design. Experience with and utilization of CCD (Cambridge Structural Database) information to inform molecular and conformational analysis and designs. Proficient in one or more programming languages (eg. Perl, C/C++, Java, Python) and knowledge of Linux/UNIX systems and utilizing cloud computing where needed. Proficient with the use of commercial platforms such as CCG, MOE, Spartan, Dotmatics, OpenEye, and Schrodinger for application to ligand design, docking, modeling, building cheminformatics, enumerating, and the design of small, focused libraries for synthesis. Experience applying modeling to improve potency, selectivity, and pharmacokinetic profiles both independently, and in parallel as part of multi-parameter optimization. Proven track record of sustained high performance and innovative project contributions, including patents, presentations and/or peer-reviewed publications. Effective communication of hypotheses, SAR analysis, and structural designs/docking experiments using graphics tools and interactive sessions. Able to engage and influence senior leadership in strategic discussions. Ability to work independently as well as in close collaboration with multidisciplinary drug discovery teams of medicinal chemists, biochemists, biophysics scientists, biologists, structural biologists, pharmacologists, and external collaborators. Duties and Responsibilities: Work collaboratively to support oncology drug discovery programs through the design of potential drugs and analysis of complex data sets. Leverage cheminformatics and bioinformatics tools for database similarity searching, small molecule modeling, and identification/analysis of protein binding sites. Facilitate the use of design, design software, and tools by the broader research group. Prepare summaries and presentations for project/chemistry teams. Potential for leadership of drug discovery projects. Publish work in peer-reviewed journals and present work both externally and internally. Stay up to date with the literature in computational and medicinal chemistry, oncology, and advances in broader methods to advance drug discovery in oncology. EEO & Employment Eligibility Turning Point Therapeutics is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Turning Point Therapeutics also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Turning Point Therapeutics is an E-Verify employer.
