The Department of Genome Analysis Unit at Amgen South San Francisco (ASF) is looking for a Computational Biology/Bioinformatics Scientist with expertise in analyzing large-scale omics data and in handing high-content NGS RNA-seq and single-cell RNA-seq data. The primary responsibilities would be to conduct computational and statistical analyses on RNA-seq, proteomics, metabolomics, flow cytometry and other high-content data from in-house data as well as public datasets for disease/patient stratification and biomarker discovery. The tasks require applying sophisticated statistical methods and/or deep-learning machine learning models. Experience with analytical method development is preferable. The Computational Biology/Bioinformatics Scientist will work with biologists, especially in immuno-oncology as well as cardiovascular relevant disease fields to leverage information on our targeted biological pathways along with computational algorithms to manage and mine internal and external NGS sequencing and other high-content databases. The successful candidate is expected to interface with the local statistical genetics/computational biology/bioinformatics community, particularly in evaluating new opportunities that advance the discovery and application of biomarkers. Basic Qualifications Doctorate Degree OR Master's degree and 4 years statistical genetics experience OR Bachelor's degree and 6 years statistical genetics experience Preferred Qualifications PhD in Computational Biology, Bioinformatics, Mathematics, Statistics, Statistical Genetics with five or more years of experience in relevant fields A working knowledge of applied mathematics or statistics to analyze large-scale omics data sets/biobanks Ability to translate biological and medical questions into analytical models providing actionable results Programming experience in languages such as R, Python or Matlab Enjoys working in collaborative team environment Record of establishing and leading lead cross-functional teams A strong scientific background with training in genetics and a proven track record of productivity Strong written and oral communication skills, self-motivation, independence and leadership Experience understanding the sources of bias arising from NGS high-content platforms, especially RNA-seq and single-cell RNA-seq Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology and is matched by an unparalleled toolbox of therapeutic modalities ranging from small molecules to peptides to proteins to antibodies to live-cell therapies. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Join Us If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen. Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.?
