COMPUTATIONAL CHEMIST, SMALL MOLECULE DRUG DISCOVERY
Organisation Name: Genentech
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Job Description:
The Position Genentech is seeking a computational chemist with experience in target discovery or validation, structure-based drug design, ligand-based design, and cheminformatics to join our Computer-Assisted Drug Discovery group in the Discovery Chemistry Department. You will be an integral member of interdisciplinary drug discovery project teams, where you will apply virtual screening, computational chemistry, informatics, and data-mining methods to help drive hit discovery and lead optimization. You will also be involved in helping to improve our “best of breed combination of computational chemistry and cheminformatics software applications and workflows. You will work closely with our Structural Biology, High Throughput Screening, Discovery Biology and other groups. You will have access to state-of-the-art hardware, software, and infrastructure support in a fast-paced and creative environment. Based at our beautiful South San Francisco campus, you will join our team of computational chemists, cheminformaticians, and software engineers who are committed to validating disease-related targets and discovering new medicines to address unmet medical needs. This is a tremendous opportunity to do impactful work in an exciting, dynamic environment. Requirements: Ph.D. or equivalent in Chemistry, Chemical Biology, Biochemistry, Biophysics, or related discipline Experience in computational chemistry, along with a strong foundation in physical organic chemistry, is required Knowledge of bioinformatics and structural biology (in particular how organic molecules interact with pockets on proteins or other biomolecules) is highly desirable Ability to give full talks about your work and relevant external developments in the field Sustained independent thought and creativity in science A solid record of accomplishment in your field as evidenced by lead or co-authored publications, patents, and internal reports Excellent interpersonal, verbal, and written communication skills Self-sufficient in scientific scripting and/or programming Practical, working experience with computational chemistry software from companies such as Chemical Computing Group, Dotmatics, Schrodinger, OpenEye, and Gaussian Industry or academic experience in small molecule drug discovery is advantageous
