Circle Pharma is a pre-clinical stage, life sciences company discovering and developing macrocycle therapeutics, with an initial focus in oncology. Our discovery platform allows us to address challenging therapeutic targets such as intracellular protein-protein interactions.

We seek candidates who desire to make key contributions to help drive our growth. For more information about Circle Pharma, please see our website, www.circlepharma.com

We are seeking a highly skilled and motivated Computational Chemist with a strong background in computational drug discovery, biomolecular simulation, and chemical informatics. Utilizing their drug design expertise, our ideal candidate will engage in drug discovery enabled by our chemistry and biology groups while also expanding both internally developed and commercial tools to perform computer-aided design of cell permeable macrocycles. Our ideal applicant will have demonstrated expertise in computational drug design, chemical information workflows, and the application of molecular simulation coupled with a strong desire to learn new techniques and incorporate new methodologies into their work, while possessing a high level of creativity, knowledge of reaction mechanisms, and strong problem-solving skills.

What You'll Do:

Serve as lead computational chemist on one or more interdisciplinary therapeutic project teams with an emphasis on structure-based and ligand-based designs, permeability predictions, developing predictive SAR, and in vitro and in vivo PK modeling
Collaboratively design, construct and evaluate targeted and general macrocycle virtual libraries for target engagement and cell permeability
Manage and analyze chemical information workflows with chemists and biologists
Assist with the development of bespoke computational algorithms, workflows, and models
Maintain currency with literature in computational medicinal chemistry

About You:

Ph.D. in computational chemistry, chemical informatics, physical organic chemistry, biophysics or related field, with at least 3 years of experience in small molecule discovery and development in the biotech/pharmaceutical industry
Trained in computational approaches to drug design and lead optimization
Experience modeling protein-ligand binding interactions using structure-based and ligand-based methods
Strong scientific programming skills (e.g., Python, Perl, R, PowerShell, Linux/Unix) with practical application of these skills is a strong plus
Excellent interpersonal, organizational, written and verbal communication skills
Team-oriented and works well in collaborative environments
Proficient in the use of Microsoft Office and ChemDraw
Excel at maintaining laboratory record of scientific findings
Self-motivated, independent, and have the ability to work with minimal supervision
Enjoy operating in an exceptionally dynamic, high-achieving and cooperative environment where every voice matters
Be able to lift 20 pounds comfortably

Preferred Experience With:

Conformational analysis of macrocycles
Chemical informatics libraries and software tools
Commercial modeling tools (Schrodinger, CCG, Cresset)
Programming with pipelining tools such as Knime
Data curation, visualization, and statistical analysis software
Creating and applying machine learning models to drug discovery

Circle Pharma is a dynamic start-up company, and our successful candidate must have the ability and desire to work in a fast-paced environment. Circle offers a comprehensive compensation package, as well as generous paid time off, in addition to Company observed holidays. The Company provides Medical, Dental and Vision Insurance, along with a retirement savings plan which includes employer contributions. We promote a culture in which employees are respected and rewarded for hard work, innovation, personal initiative, and teamwork.

Circle Pharma is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, gender identity, disability status, membership in an organization or any other non-merit factors.

While COVID-19 has affected the way we operate, we are still hiring, and look forward to receiving your application! Here at Circle Pharma, the health of our team members is a top priority. Our application process for prospective new team members will include initial virtual video interviews and may also include in-person interviews during which we will pay special attention to the distance and hygiene rules recommended by the CDC. We recognize that these are difficult times, and we are doing everything possible to keep our employees safe while also conducting our work to bring new cancer therapies to patients.

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Scientist, Computational Chemistry

What You'll Do:

About You:

Preferred Experience With: