Job Description:
Who We Are:At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options. What We Do:Neurocrine Biosciences is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson’s disease, endometriosis* and uterine fibroids*, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. *in collaboration with AbbVie About the Role:We are seeking an exceptionally talented and highly motived computational chemist who will enhance our molecular design capabilities across multiple drug discovery programs. The successful candidate will be responsible for the implementation and execution of innovative computational methodologies and tools to support drug discovery programs from target identification through lead optimization and ultimately drug candidate selection. They will work as part of multi-disciplinary teams of medicinal chemists, structural biologists, pharmacologists and AMDE/Tox representatives to provide computational expertise to rapidly advance projects. They will have the opportunity to work across multiple modalities including small molecules, peptides and biologics. We seek a truly hands on individual that has a passion for improving the design-make-test-analyze cycle. This is an exciting time to join our rapidly growing research department and help shape our newly formed Enabling Technologies group._ Your Contributions (include, but not limited to): Champion and promote the use of computational chemistry and cheminformatics methods to expedite the Design-Make-Test-Analyze discovery cycle Provide project teams with computational strategies to inform, influence, and prioritize designs for potency/selectivity and improve ADME/Tox endpoints Contribute to the strategy and execution of small molecule drug discovery programs, working closely with cross-functional project teams in a matrix environment Facilitate the medicinal chemists design of complex molecules and predict their properties using cutting-edge technologies integrating structural, chemical and biological data Lead by example in the application of in silico technologies to small molecule drug discovery programs Innovate and implement new technologies to accelerate and improve small molecule design Identify and assess emerging computational methodologies, including AI/ML, and contribute to the scientific development direction for the group Mentor scientific staff and contribute to their scientific and career development Participate in shaping and implementing strategies that support innovative and efficient drug discovery, by researching and incorporating new techniques, modalities, and platforms Serve as a scientific expert in computational chemistry with both internal and external partners and provide recommendations regarding new targets and emerging external opportunities Ensure optimal interaction/communication and provide updates on project status to senior technical leadership Execute sophisticated experiments using advanced computational techniques on computers internally and on the cloud to drive decision-making in project teams Other duties as assigned
Requirements:PhD in computational chemistry, organic chemistry or a related field and 4+ years of experience applying computational chemistry in a drug discovery setting with a track record of key contributions to compound progression is required OR Masters in computational chemistry or related field and 10+ years of similar experience noted above OR Bachelors in chemistry or related field and 12+ years of similar experience noted above Expertise in ligand and structure-based drug design related to small molecules as well as other modalities including: peptides, biologics and targeted protein degradation Experience with a variety of computational tools and methodologies including docking, virtual screening, molecular dynamics, free energy perturbation, homology modeling, and pharmacophore elucidation Experience in leveraging data to develop AI/machine learning models Experience in data mining and data analysis Proficiency in programming computational workflows in Knime or equivalent Experience working with colleagues in Med Chem and Structural Biology and provide input to inform design and improvements in potency, selectivity, and ADME/Tox endpoints Familiarity with standard computational chemistry packages such as Maestro/Schrodinger, MOE/Chemical Computing Group, and/or OpenEye tools Familiar with common scripting and programming languages Experience with one or more of the following is preferred: targeted protein degradation, DNA-encoded libraries, and/or peptide-based therapeutics. Strong record of scientific contributions including peer-reviewed first-author publications, patent applications, and presentations at major national meetings Assimilates data and research findings outside of Neurocrine for application to new scientific projects Maintains broad knowledge of scientific principles and theories and possesses intellectual mastery of one or more scientific areas May develop an understanding of other areas and related dependencies Ability to work as part of project teams and serve as a functional expert Exhibits leadership skill and ability, typically leads lower levels and/or indirect teams Excellent communications, problem-solving, analytical thinking skills Sees broader picture, impact on multiple programs, teams and/or departments Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency Excellent project management skills Demonstrated influence, and conflict resolution skills, including the ability to succeed within a matrix environment are required
#LI-SA1 Neurocrine Biosciences is an EEO/AA/Disability/Vets employer. As a condition of employment with Neurocrine Biosciences, Inc. in the United States, you must be fully vaccinated for COVID-19 and provide valid proof of vaccination to the company. |
