About the role:
DeepCure is seeking an exceptional and highly-motivated Computational Chemist to join our fast-growing collaborative team and contribute to redefining drug discovery. In this role, you will use our transformative Artificial Intelligence (AI) platform, contribute to and apply cutting-edge technologies, and help us shape the company’s scientific vision. You will work hand-in-hand with other drug discovery scientists, machine learning scientists and software engineers to build and develop a portfolio of programs to find cures to unmet medical needs. This is a unique position – as a member of a fast growing early-stage company your contributions will have a significant impact on the science and you will have tremendous opportunity for growth as the company expands.
More about DeepCure:
DeepCure is a next-generation therapeutics company, built from the ground-up with equal importance assigned to computation and life-sciences. Our mission is to deliver to patients safer and more efficacious therapeutics that are extremely unlikely to be discovered by traditional drug discovery pipelines. We are a team of curious, multidisciplinary, and impact-driven professionals on a quest to redefine the way drugs are discovered.
In this role you will:
- Contribute scientifically and strategically as an integral member of project teams to deliver clinical candidates.
- Devise computational strategies to identify lead-like molecules and optimize compounds that will target multiple cellular pathways/mechanisms.
- Apply and/or develop computational strategies to improve efficacy, drug-likeness, ADME/DMPK, and safety properties of molecules.
- Apply and/or contribute to the development of new computational approaches for expansion into unique chemistry space.
- Conduct research into new computational chemistry tools and methods relevant to DeepCure’s mission.
- Communicate computational results and analysis to project team members and stakeholders.
- Support Discovery Programs needs via strong interactions with the MedChem group (not merely performing calculations/simulations on-demand, but proactively providing inputs related to hit finding and hit-to-lead optimization
Required Qualifications:
- Ph.D. in computational chemistry, biophysics, physical organic chemistry or a related discipline.
- A passion for drug discovery and a working understanding of medicinal chemistry concepts.
- 2 to 4 years of academic (PostDoc) or industry experience in small molecule drug discovery research (hiring level commensurate with experience).
- Practical working experience with computational chemistry software (e.g., Schrodinger, ICM Molsoft, OpenEye, CCG, others) and cloud-based computing.
- Proven expertise in one or more of the following: docking studies, virtual screening, druggability analysis, structure-based design for lead optimization, free energy perturbation, and molecular dynamics simulation.
- Comfortable and familiar with working on the command line and scripting.
- Excellent ability to communicate demonstrated through scientific publications and presentations.
- Preference will be given to candidates who are currently authorized to work in the United States.
Preferred Qualifications:
- Basic programming skills (python, Jupyter notebook, bash).
- Demonstrated ability to innovate within strong multidisciplinary project teams and internal/external partners.
For the right candidate, we'll offer a competitive salary and a generous equity grant. Your compensation is rounded out by a strong benefits package:
- A leadership team that values and prioritizes your professional development.
- Flexible work hours.
- Unlimited paid leave and sick time.
- 401(k) plan with employer matching.
- Healthcare, vision, dental, and life insurance plans for you and your dependents.
- FSA with employer contribution for medical expenses
- Generous parental leave.
- Tax-advantaged commuter benefits for public transportation or parking.
- Work in a cool and vibrant space at the heart of Boston or anywhere else in the world.
- This position is open for remote employment, within the united states.
Most importantly, you'll have a huge impact, do important work, and work with a team of people you'll genuinely enjoy spending the day with.
“Brainstorming on my challenges with all these amazing brains, deserves a shout-out every sprint” (Jon, Member of our Machine learning team).
DeepCure is an equal opportunity employer, dedicated to creating a workplace that is free of harassment and discrimination. We base our employment decisions on business needs, job requirements, and qualifications — that's all. We do not discriminate based on race, gender, religion, health, personal beliefs, age, family or parental status, or any other status. We don't tolerate any kind of discrimination or bias, and we are looking for teammates who feel the same way.
