Working with Us Challenging. Meaningful. Life-changing. Those arent words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here uniquely interesting work happens every day in every department. From optimizing a production line to the latest breakthroughs in cell therapy this is work that transforms the lives of patients and the careers of those who do it. Youll get the chance to grow and thrive through opportunities uncommon in scale and scope alongside high-achieving teams rich in diversity. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits services and programs that provide our employees with the resources to pursue their goals both at work and in their personal lives. Read more: careers.bms.com/working-with-us. At Bristol Myers Squibb we are inspired by a single vision transforming patients lives through science. In oncology hematology immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference. Position Summary We seek a highly motivated student to join our Predictive Sciences group within the Oncogenesis Thematic Research Center for a 10-week summer internship program. A successful candidate will work with their mentor to interrogate the biological functions of oncogenic transcription factors Ikaros and Aiolos in Diffuse Large B Cell Lymphoma (DLBCL) by a retrospective analysis of multi-modal omics data. DLBCL is an aggressive heterogeneous disease with poor prognosis associated with cell of origin or high-risk molecular features. Ikaros and Aiolos have been identified as key oncogenic drivers for DLBCL. Over the years BMS has developed multiple cereblon (CRBN) modulating agents from first-generation compounds like lenalidomide and pomalidomide to more recent golcadomide to induce targeted degradation of Ikaros and Aiolos by hijacking the ubiquitin proteasome system. However the specific regulatory roles and biological functions of Ikaros and Aiolos in DLBCL remain obscure. Recent advances in CUT&RUN have enabled high-quality profiling of Ikaros and Aiolos binding landscape. With the CUT&RUN capability being established within the Oncogenesis TRC and a large collection of genetic and epigenetic profiling we have accumulated over the years for a panel of DLBCL cell models (e.g. ChIP-seq ATAC-seq Micro-C/Hi-C RNA-seq WGS WGBS and genome-wide CRISPR screen) we expect the successful candidate to apply and/or develop effective data-driven methods to analyze mine and interpretate the data towards a better understanding of Ikaros and Aiolos biological functions in DLBCL. As a leading company in Targeted Protein Degradation (TPD) this intern will provide an exciting opportunity for the candidate to have an immersive experience of the development of protein degrader drugs. The candidate will also have opportunities to learn from experienced computational and experimental biologists and hone the skills in applying data-driven methods to tackle challenges in new drug development. Key Responsibilities Perform in-depth analysis of CUT&RUN data to map the cell-type-specific binding landscape of Ikaros and Aiolos across a panel of DLBCL models and generate hypotheses linked to phenotype (e.g. sensitivity to Ikaros and Aiolos degradation). Contextualize the hypothesized functions of Ikaros and Aiolos within the genetic and epigenetic landscapes of a panel of DLBCL cell models by data-driven methods and literature search. Deliver and communicate analyses results to the team. Qualifications & Experience Currently enrolled in a Ph.D program in physical sciences life sciences bioinformatics computer sciences or a related field. Strong interests in solving biological problems by applying quantitative skills. Hands-on experience in genetic and/or epigenetic profiling techniques (e.g. CUT&RUN ChIP-seq and WGBS) is required. Experience in Python programming language (e.g. pandas numpy) or R. Familiarity with public omics data consortiums (e.g. TCGA DepMap and ENCODE) is preferred but not required. Familiarity with enhancer biology and higher-order chromatin structure is preferred but not required. Must be able to work full-time for the program duration. Excellent communication and presentation skills. Why You Should Apply Around the world we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture our shared values of passion innovation urgency accountability inclusion and integrity bring out the highest potential of each of our colleagues. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits services and programs that provide our employees with the resources to pursue their goals both at work and in their personal lives. BMSEC BMSINTERN BMSCO-OP If you come across a role that intrigues you but doesnt perfectly line up with your resume we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work Life-changing Careers With a single vision as inspiring as Transforming patients lives through science every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture promoting diversity in clinical trials while our shared values of passion innovation urgency accountability inclusion and integrity bring out the highest potential of each of our colleagues. On-site Protocol Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role which the Company deems critical to collaboration innovation productivity employee well-being and engagement and it enhances the Company culture. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application or in any part of the recruitment process direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff customers patients and communities. As a result the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records pursuant to applicable laws in your area. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
