Research Prime

Computational Biologist/Research Scientist

Organisation Name: The Masonic Medical Research Institute
Organisation Type:
City: Utica
State: Utica, NY
Country: United States

Job Description:

Description

The Masonic Medical Research Institute (mmri.edu) is looking for enthusiastic candidates at any career stage to join the laboratory of Dr. Nathan Tucker (www.mmri.edu/tucker-lab/). Successful candidates will join a research program which focuses on mechanistically understanding the effects of human genetic variation (such as that identified by GWAS) on cardiovascular phenotypes. To reach these goals, we travel a research path that requires the coordination and collaboration of both laboratory and computational team members. While a base level of experience will be important for a successful candidate, we equally weigh enthusiasm, curiosity, long-term potential, and team fit for anyone who might join the lab. We will consider individuals with exclusive focus on either bench science or computational work and those with blended experience/interest between the two. The important thing is that your goals fit with those of the group, and that our group is a good fit for you.


Specific projects include defining epigenomic and transcriptomic changes in normal and disease conditions, single-cell sequencing for discovery and definition of novel cell states in human disease, large-scale CRISPR-mediated screening of coding and non-coding variant function, assessment of disease-causing variation in model organisms, and intersection of all previously mentioned data with human population genetics and health outcome data.


In addition to internally driven projects, our group also has extensive national and international collaborations, including with groups at the Broad Institute of MIT and Harvard, Columbia University, Massachusetts General Hospital, the University of Pennsylvania, Vanderbilt University, and others.


For more information, please visit our lab website at www.mmri.edu/genetics/


For a full listing of published work, please visit: https://scholar.google.com/citations?

user=ZVR6v_MAAAAJ&hl=en&oi=ao


See a few examples of our recent work below:


https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.122.010119

https://www.nature.com/articles/s41586-022-04817-8

https://insight.jci.org/articles/view/154633

We provide:
  • An opportunity to present your work at national/international conferences.
  • Support for publication of high and medium impact journal articles. We are also strong advocates of preprints.
  • A supportive environment that keeps your short and long-term career goals in mind. Your success is our success!
  • Clear expectations provided in structured project management.
  • A closely-knit, exceptionally equipped research institute with a wide variety of research interests and expertise.
  • An appreciation for work/life balance; sometimes the best ideas come when not in the lab!
  • A highly competitive compensation and benefits packages
  • A position in the very affordable Mohawk Valley of Upstate New York: an ideal region for those interested in myriad outdoor adventures including those in the Adirondack State Park, the largest park in the contiguous United States.
  • Opportunities for Hybrid work will be considered after initial period.
Requirements
Computational Biologist Focus
  • Higher degree in computational biology, computer science, physics, statistics, math, molecular biology, bioinformatics or related field. Talented applicants of all levels are encouraged to apply.
  • Experience with statistical methods in biological data analysis
  • Fluency in Unix, R, Python, and/or MATLAB
  • Experience with high-performance computing and cloud computing environments
  • Any previous experience with single cell sequencing or genomic sequence data is highly desirable
Research Scientist focus
  • Ph.D. in biological sciences or related field. History of high-quality published work regardless of the journal and its impact factor
Experience with any of the following:
  • Molecular biology including CRISPR-Cas9 approaches, next generation sequencing, plasmid and/or viral work, epigenomic profiling, etc.
  • Cell biology including various forms of microscopy, flow cytometry, etc.
  • Animal model systems of cardiovascular disease
  • Low-input molecular profiling approaches such as single cell sequencing, spatial transcriptomic profiling, etc.
For any role:
  • A general love of science and all the challenges that come with it.
  • Excitement to tackle challenging, multidisciplinary scientific questions in areas involving development of technical and analytical workflows.
  • Scientific creativity to identify and evaluate novel approaches to answer our research questions.
  • A hard working and collegial attitude
  • A desire to work in a relatively informal, highly collaborative, and scientifically rigorous team-centered laboratory environment.

Posting Date: Jul 13, 2023
Closing Date:
Organisation Website/Careers Page: https://recruiting.paylocity.com/Recruiting/Jobs/Details/1810662


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