About the
Department
The Protein Engineering department is part of Novo Nordisk’s
Computational Drug Design (CDD) area where we apply and develop
state-of-the-art capabilities in structure-based modelling and
AI/ML approaches for drug design. Scientists within CDD
collaborate seamlessly with teams across the globe to invent
better molecules faster. With an unbiased approach to drug
modalities, in-house access to the newest screening techniques,
and world-class experimentation, we have a wealth of
opportunities to impact our pipeline and ultimately save and
improve patient lives. We work in multidisciplinary, highly
collaborative discovery teams both locally and across Novo
Nordisk’s global network to invent novel medicines by applying
advanced computational techniques and developing innovative
computational methods. We also engage in external collaborations
to ensure access to cutting edge research and
technology.
The Protein Engineering team is focusing on the
design of biopharmaceutical proteins such as protein minibinder
and protein replacement therapies, using Molecular Modelling and
Machine Learning approaches. We collaborate closely with our
experimental colleagues in early research to improve and
accelerate the design of new drug candidates. With a team of
scientists located in Denmark, United States and potentially
also United Kingdom, we strive to deliver the latest
advancements in protein therapeutics to benefit patient health
and global medicine.
The Position
The Senior Data Scientist I will contribute to the research
team's effort towards exploring and creating new technology and
being a world leader in data science within our fields. A key
part of the role will be to work within the drug development
projects in early research and support the development of new
drug candidates as well as the initiation of new drug pipeline
projects. This requires close collaboration with other research
scientists in multidisciplinary teams and solving very ambitious
scientific goals. The position also requires close collaboration
with our data science and machine learning colleagues across the
global sites of the ‘Digital Science & Innovation’ area as
well as to contribute to the onboarding and development of new
computational drug design methods. For this position, we are
looking for someone with experience and interests in de novo
design of protein minibinder, and/or protein engineering of
enzymes and other biopharmaceutical proteins.
***Please note we are open to hiring at more senior titles
commensurate with experience***
Open to candidates located in either Seattle, WA or Lexington, MA -
this is a hybrid role with weekly time in office required
Relationships
The Senior Data Scientist I reports to the head of Protein
Engineering. Internal partners include data scientists,
specialists, engineers, software developers, technology scouts
& partnership developers, system engineers, designers,
anthropologists, medical doctors, IT professionals, and others
across US and Denmark.
External relationships include commercial and academic
collaboration partners.
Essential Functions
- Apply computational methods to guide the design of
biologics, including de novo design of proteins and
optimization of biopharmaceutical properties of proteins and
enzymes via structure- and ML-based methods
- Apply predictive models for biologics design, including
developability engineering and experimental design of
high-throughput variant libraries.
- Influences the research pipeline by proposing new compound
design projects that support the strategic in-house research agenda
Physical Requirements
0-10% overnight travel required.
Qualifications
- Master’s degree, or PhD is preferred. Bachelor’s degree
required. Degree within within a computational chemistry or
biology discipline, such as Computational Protein Design or
Molecular Modelling preferred
- A master’s degree with 3+ years’ relevant experience, or
PhD with little to no years’ relevant experience,
OR Bachelor’s degree with 5+ years’ relevant experience can be considered
- Relevant experience includes some combination of:
- Research experience in the field of protein
therapeutics/design within industry or academics (industry preferred)
- Knowledgeable in applying structure-based computational
drug design techniques, preferably for protein minibinder,
enzymes, or other biopharmaceutical proteins.
- Experience with protein modelling software such as
Rosetta, Schrodinger and/or MOE.
- Experience working in Python (or other scientific
programming language) to curate and analyze data
- Experience in working in multidisciplinary teams and
working environment(s)
- Ability to perform in-depth data analysis and present
results and conclusions to project and leadership teams
- Excellent written and oral communication skills
- Detail oriented with strong presentation and
documentation skills
- Preferred experience includes:
- Drug discovery experience in the field of biologics
- De novo protein design
- Experience with QSAR analysis and Machine Learning for
property predictions or design of compounds
- Experience working with cloud compute services such as
AWS S3, EC2 or Azure
We commit to an inclusive recruitment process and equality
of opportunity for all our job applicants.
At Novo Nordisk we recognize that it is no longer good
enough to aspire to be the best company in the world. We need to
aspire to be the best company for the world and we know that
this is only possible with talented employees with diverse
perspectives, backgrounds and cultures. We are therefore
committed to creating an inclusive culture that celebrates the
diversity of our employees, the patients we serve and
communities we operate in. Together, we’re life changing.
Novo Nordisk is an equal opportunity employer. Qualified
applicants will receive consideration for employment without
regard to race, ethnicity, color, religion, sex, gender
identity, sexual orientation, national origin, disability,
protected veteran status or any other characteristic protected
by local, state or federal laws, rules or regulations.
This position is part of a job family. As a result, this
position can be filled with varying job titles depending on
experience. The ranges for the job titles are the following -
• Sr. Data Scientist I or Sr. Data Scientist II- - $98,820 -
172,940
• Lead Data Scientist or Sr. Lead Data Scientist
$121,050- 195,000
Base compensation is determined based on a number of
factors. In addition, this position is part of the Annual
Performance Incentive Plan. The role may also be eligible for a
long-term incentive bonus depending on level and other Company factors.
Employees are also eligible to participate in Company
employee benefit programs including medical, dental and vision
coverage; life insurance; disability insurance; 401(k) savings
plan; flexible spending accounts; employee assistance program;
tuition reimbursement program; and voluntary benefits such as
group legal, critical illness, identity theft protection, pet
insurance and auto/home insurance. The Company also offers time
off pursuant to its uncapped sick time policy, flex-able
vacation policy, and parental leave policy.
If you are interested in applying to Novo Nordisk and need
special assistance or an accommodation to apply, please call us
at 1-855-411-5290. This contact is for accommodation requests
only and cannot be used to inquire about the status of applications.