Overview:

The Qi laboratory at the Dana-Farber Cancer Institute is looking for exceptional Postdoctoral Fellows in cancer biology (qi lab website: qilab.dana-farber.org). The Qi lab studies gene regulatory pathways using the emerging discipline of chemical biology. Successful candidates will work with an interdisciplinary team of scientists including medicinal chemists biochemists computational biologists and cancer biologists to develop novel inhibitors of chromatin modifying enzymes such as methyltransferases demethylases and bromodomains. The successful candidate will perform research that will help make fundamental insights to cancer biology using novel small molecule inhibitors to gain mechanistic understanding in cancer therapy. We expect that novel therapeutics for human clinical investigation will emerge directly from these efforts through academic/industry collaborations. The postdoctoral fellow will be affiliated with the Department of Cancer Biology at Dana-Farber Cancer Institute the Department of Medicine at Harvard Medical School and the Broad Institute.

Located in Boston and the surrounding communities Dana-Farber Cancer Institute brings together world renowned clinicians innovative researchers and dedicated professionals allies in the common mission of conquering cancer HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners including other Harvard Medical School-affiliated hospitals.

Responsibilities:

Qi lab is seeking an enthusiastic and experienced bench-level fellow to join our team. The major focus of this position will include developing and executing biological assays for inhibitor discovery and characterization while investigating novel biological mechanisms of action.

Specific responsibilities include:

• Performing cell and molecular biology research including but not limited to tissue culture genetic manipulation through shRNA/CRISPR routine protein/RNA/DNA analyses including ChIP-seq and RNA-seq.
• Performing laboratory experiments and conducting data analysis.
• Designing experiments and executing protocols.
• Maintaining accurate records writing reports and preparing/giving presentations.
• Performing preclinical translational studies in mouse models of cancer if it is interested.

Qualifications:

• PhD or MD/PhD in biological sciences or equivalent
• A strong background in biochemistry cancer biology molecular biology and/or cell biology.
• Experience with mouse models of cancer (xenografts PDXs GEMMs) is a plus.
• Excellent oral and written communication skills.
• The ability to perform both self-directed and guided research is required.
• Must demonstrate outstanding ability to work effectively as part of an interdisciplinary team of scientists.

At Dana-Farber Cancer Institute we work every day to create an innovative caring and inclusive environment where every patient family and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals neither do we. If working in this kind of organization inspires you we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race color religion sex gender identity or expression national origin sexual orientation genetic information disability age ancestry military service protected veteran status or other groups as protected by law.