Job Description:
Building a map of human biology is uncharted territory. Come help us pave the way.
Nine years ago, we were staining plates by hand. Today, we've created a library of more than one billion cellular images on the basis of a radically different approach to biotech. This is a bold approach that we believe will reinvent drug discovery and development.
If you draw a line from nine years ago to today, you’ll see our trajectory and understand that Recursion is a very different kind of company. You cannot make these kinds of leaps simply by adding incubators, fluorescent microscopes, and robots to automate processes at scale. Our drug discovery strategies are map and data-driven rather than target-driven, revealing destinations you might never have considered. As a Principal Scientist at Recursion, you’ll be in a position to directly accelerate the timeline of getting drugs into the hands of patients who need them.
The Impact You’ll Make
You will engage in early drug discovery projects from launch to preclinical development and help our efforts in advancing new therapeutics to patients. You will be at the forefront of developing new approaches that reimagine small molecule drug discovery leveraging Recursion’s extensive data capabilities. As a Principal Scientist, you will:
- Build - In partnership with medicinal chemists, biologists, data scientists, and others, you will build projects across therapeutic models designed to translate phenotypic screening hits to preclinical assets with quality and speed
- Lead - You will lead cross-functional computational and medicinal chemistry efforts, as part of a nimble, highly efficient chemistry team
- Collaborate - Work in a cross-functional matrix organization with biologists, chemists, data scientists, and engineers with a passion for drug discovery
- Communicate - Independently prepare impactful presentations for senior leaders and partners to allow for informed data-based decision-making
- Achieve - Understand the critical path and provide high-quality results
The Team You’ll Join
Reporting to our Director of Applied Chemistry, you will be a leader within our discovery organization, partnering with others to build and advance the portfolio of preclinical small molecule NCE and repurposed assets. You will use your depth and breadth of understanding of computational and medicinal chemistry to lead molecular modeling efforts that inform programs and find synergistic opportunities to capitalize on Recursion’s AI-enabled high throughput phenotypic screening platform. You will work in a highly matrixed organization to advance molecules from hit identification to lead series and ultimately to candidate status. Your skills will be of high value as you work cross-functionally internally, with external stakeholders and contract chemistry FTEs.
The Experience You’ll Need
- Ph.D. in computational chemistry, biophysics, medicinal chemistry, engineering, or equivalent
- 5+ years as a computational chemistry program lead in drug discovery/development within a biotech or pharma setting
- Strong record of delivery as demonstrated by publications, presentations, patents, or other evidence of creative application of computational approaches to problems of pharmaceutical interest
- Proficiency in general molecular modeling techniques (docking, molecular simulation, homology modeling, quantum mechanics, pharmacophore and shape screening, ligand- and structure-based design)
- Experience providing project teams with computational strategies to inform, influence, and prioritize designs for potency/selectivity and improve ADME/Tox endpoints
- Experience in contributing to the identification, development, validation, and implementation of innovative computational approaches that improve research productivity and success
Preferred Experience and Skills:
- Experience with Linux and HPC environments.
- Proficiency with modeling software packages (e.g. Maestro, LiveDesign, MOE, OpenEye, Rosetta, etc.).
- Proficiency in scientific scripting and programming languages (e.g. Bash, Python)
|
