Research Prime

Lead or Senior Computational Chemist

Organisation Name: Meliora Therapeutics
Organisation Type:
City:
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Country: United States

Job Description:

We are looking for a talented and ambitious computational chemist who is passionate about making a difference in cancer care and loves working in the startup environment. Apply your expertise in Chemistry, Computational Chemistry, Cheminformatics or a related discipline in establishing the company’s capabilities in molecular design and drug development.

You will play a significant role in developing the algorithmic engine of the company.  You will understand company goals and drive towards those goals, providing feedback about new opportunities and illuminating roadblocks when they occur. We value your unyielding scientific rigor and desire to continuously learn. The computational chemist will work collaboratively with a multi-disciplinary, international team, seeking excellence at every turn.


What you’ll do:

  • Roll up your sleeves and bring your skills and experience in computational chemistry and drug development to bear on a critical problem in cancer drug discovery –  improving the success rate of cancer drugs brought to clinical trials.
  • Apply the latest cheminformatics, computational chemistry, and/or molecular modeling strategies in order to build bridges linking cheminformatics, quantitative SAR modeling, and molecular modeling. This role features close interaction with interdisciplinary drug discovery project teams, including medicinal chemistry, discovery pharmacology and bioinformatics
  • Spearhead small molecule library design while applying powerful analytic and visualization methods to explore structure-activity relationships
  • Bring your curiosity and collegiality to our growing team.
  • Be a culture setter by embodying the company’s principles of scientific and computational curiosity and rigor, mutual respect, personal integrity, drive, and collaboration.

Background and skills we are looking for:

  • Ph.D, in Chemistry, Computational Chemistry, Cheminformatics or a related discipline
  • Significant expertise modeling chemical and biology data in a drug discovery setting;
  • Experience as a lead or manager of drug development program including expertise with principles of medicinal chemistry, ADME, PK and other key milestones required for clinical drug development
  • Expertise in using molecular modeling and machine learning techniques to analyze and gain insight from biological or other data including cheminformatics libraries, such as TensorFlow, Keras, PyTorch, Pandas, Scikit-Learn, DeepChem, RDKit, or OEchem
  • Excellent communication skills to synthesize complex technical problems and solutions into content easily understandable by the scientific and leadership teams to facilitate critical decisions
  • Ability to be highly successful operating in a multidisciplinary environment and a willingness to collaborate across functional teams is essential

What we offer:

  • Highly competitive compensation with equity
  • Medical, dental, and vision insurance plans
  • Remote work
  • The opportunity to have your career grow along with our company
  • Work focused on developing cutting-edge technical methodologies to directly create meaningful positive impact on human health
  • The freedom to develop your own methodologies and approaches in collaboration with our team to solve our most important challenges
  • The opportunity to work with a world-class interdisciplinary team with expertise spanning numerous fields in biology, computer science, and machine learning. We learn from each other everyday and we’re excited to continue learning as we grow!
  • Quarterly US based travel for on-site retreats



Posting Date: Apr 11, 2023
Closing Date:
Organisation Website/Careers Page: https://www.melioratherapeutics.com/careers


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